This will open the file in the default audio player:
// JScript
Sys.OleObject("WScript.Shell").Run("C:\\Users\\Helen\\Desktop\\File.mp3");
If the file path has spaces, put extra quotes around it:
// JScript
Sys.OleObject("WScript.Shell").Run("\"C:\\Users\\Helen\\Desktop\\My File.mp3\"");
// or
Sys.OleObject("WScript.Shell").Run(aqString.Quote("C:\\Users\\Helen\\Desktop\\My File.mp3"));
If you don't want to hardcode the Desktop folder path, you can get it programmatically:
// JScript
var oShell = Sys.OleObject("WScript.Shell");
var strDesktop = oShell.SpecialFolders("Desktop");
var strFileName = aqFileSystem.IncludeTrailingBackSlash(strDesktop) + "My File.mp3";
oShell.Run(aqString.Quote(strFileName));
More info:
Run Method (Windows Script Host)