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What i found about win32 api for Python. It turned out that win32com.client couldn't be imported more than once within the same process. Sorry, this is a limitation of the PyGILState API used by pywin32; pywin32 will never be able to play with the multiple interpreter API, nor work correctly with multiple interpreter initializations and cleanups. But such problem occurs with another libraries. For example, with lxml. Second import cause Test Complete crash :)