Regions.Compare images including mouse?

I believe you meant to use picture compare method and not the region compare.

Edit:

Also you need to specify the mouse pointer exclusion when you use the .Picture() method.

See documentation here.

Try this (again, lol):

var wnd = Aliases.Application.MainWindow;
var obj = wnd.Studio.ScrollViewer.ScrollViewer

//take first picture specifying mouse is not to be captured
var pic1 = obj.Picture(0, 0, -1, -1, false);

//perform object drag
wnd.Pulses.Drag(104, 220, 385, 13);

//take second picture specifying mouse is not to be captured
var pic2 = obj.Picture(0, 0, -1, -1, false);
pic1.Compare(pic2);