java.net.ConnectException: Connection timed out

I'm using the latest maintence version of SoapUI (not pro).  if I submit a small SOAP message, it works.  When I submit a large message I get a timeout.  I tried changing the preferences, HTTP settings, socket timeout to a really large number (x10) but it doesn't seem to actually increase the time it takes to actually get the timeout message.  I tried setting it to 0 and get the same result.

Thu Feb 19 13:23:10 EST 2015:ERROR:org.apache.http.conn.HttpHostConnectException: Connection to http://myserver.com refused

   org.apache.http.conn.HttpHostConnectException: Connection to http://myserver.com refused

    at com.eviware.soapui.impl.wsdl.support.http.SoapUIMultiThreadedHttpConnectionManager$SoapUIClientConnectionOperator.openConnection(SoapUIMultiThreadedHttpConnectionManager.java:332)

    at org.apache.http.impl.conn.AbstractPoolEntry.open(AbstractPoolEntry.java:149)

    at org.apache.http.impl.conn.AbstractPooledConnAdapter.open(AbstractPooledConnAdapter.java:121)

    at org.apache.http.impl.client.DefaultRequestDirector.tryConnect(DefaultRequestDirector.java:561)

    at org.apache.http.impl.client.DefaultRequestDirector.execute(DefaultRequestDirector.java:415)

    at org.apache.http.impl.client.AbstractHttpClient.execute(AbstractHttpClient.java:820)

    at org.apache.http.impl.client.AbstractHttpClient.execute(AbstractHttpClient.java:754)

    at com.eviware.soapui.impl.wsdl.support.http.HttpClientSupport$Helper.execute(HttpClientSupport.java:247)

    at com.eviware.soapui.impl.wsdl.support.http.HttpClientSupport.execute(HttpClientSupport.java:362)

    at com.eviware.soapui.impl.wsdl.submit.transports.http.HttpClientRequestTransport.submitRequest(HttpClientRequestTransport.java:324)

    at com.eviware.soapui.impl.wsdl.submit.transports.http.HttpClientRequestTransport.sendRequest(HttpClientRequestTransport.java:237)

    at com.eviware.soapui.impl.wsdl.WsdlSubmit.run(WsdlSubmit.java:127)

    at com.eviware.soapui.impl.wsdl.WsdlSubmit.submitRequest(WsdlSubmit.java:80)

    at com.eviware.soapui.impl.wsdl.WsdlRequest.submit(WsdlRequest.java:242)

    at com.eviware.soapui.impl.wsdl.teststeps.WsdlTestRequestStep.run(WsdlTestRequestStep.java:419)

    at com.eviware.soapui.impl.wsdl.support.AbstractTestCaseRunner.runTestStep(AbstractTestCaseRunner.java:239)

    at com.eviware.soapui.impl.wsdl.testcase.WsdlTestCaseRunner.runCurrentTestStep(WsdlTestCaseRunner.java:52)

    at com.eviware.soapui.impl.wsdl.support.AbstractTestCaseRunner.internalRun(AbstractTestCaseRunner.java:152)

    at com.eviware.soapui.impl.wsdl.support.AbstractTestCaseRunner.internalRun(AbstractTestCaseRunner.java:47)

    at com.eviware.soapui.impl.wsdl.support.AbstractTestRunner.run(AbstractTestRunner.java:139)

    at java.util.concurrent.Executors$RunnableAdapter.call(Executors.java:471)

    at java.util.concurrent.FutureTask.run(FutureTask.java:262)

    at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1145)

    at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:615)

    at java.lang.Thread.run(Thread.java:745)

   Caused by: java.net.ConnectException: Connection timed out

    at java.net.PlainSocketImpl.socketConnect(Native Method)

    at java.net.AbstractPlainSocketImpl.doConnect(AbstractPlainSocketImpl.java:339)

    at java.net.AbstractPlainSocketImpl.connectToAddress(AbstractPlainSocketImpl.java:200)

    at java.net.AbstractPlainSocketImpl.connect(AbstractPlainSocketImpl.java:182)

    at java.net.SocksSocketImpl.connect(SocksSocketImpl.java:363)

    at java.net.Socket.connect(Socket.java:579)

    at org.apache.http.conn.scheme.PlainSocketFactory.connectSocket(PlainSocketFactory.java:123)

    at com.eviware.soapui.impl.wsdl.support.http.SoapUIMultiThreadedHttpConnectionManager$SoapUIClientConnectionOperator.openConnection(SoapUIMultiThreadedHttpConnectionManager.java:310)

    ... 24 more