When I close ReadyAPI, I'm prompted with a dialog box asking if I really want to edit. This box appears regardless of whether I've made any changes, or if I have the auto-save project option enabled ...
The issue is it's really annoying to be forced to confirm something you are deliberately doing. Imagine every time you want to send an email, your email client asked if you were sure you wanted to send the message.
The best way to prevent accidental data loss is default the auto-save option to True. That way there's no chance of losing changes. I'm not sure why ReadyAPI doesn't do this.